Application

Ubiquitination Cascade Comoponent:Substrate

Recombinant human Kit, amino acids 544-end. N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

Disclaimer

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General description

AXIS Axon Isolation Devices, 150 µm long channels, 10 devices

Kit belongs to the family of type III receptor tyrosine kinases. It mediates the cellular response to stem cell factor and plays a major role in survival, expansion and differentiation of haematopoietic progenitor cells and reproductive stem cells. The activation of Kit is tightly regulated and uncontrolled Kit activity contributes to the growth of diverse human tumours. Gain-of-function mutations have been described in a number of malignancies, including acute myeloid leukaemia, small cell lung cancer, gastrointestinal stromal tumours and testicular cancer. Negative regulation of Kit signalling has been shown to occur mainly through ubiquitin-mediated internalization and degradation of the receptor.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Format: Purified using glutathione sepharose.